Stem cell research
Cell wikipedia, the free to: navigation, stem cell controversy is the consideration of the ethics of research involving the development, use, and destruction of human embryos. For example, adult stem cells, amniotic stem cells, and induced pluripotent stem cells do not involve creating, using, or destroying human embryos, and thus are minimally, if at all, controversial. Many less controversial sources of acquiring stem cells include using cells from the umbilical cord, breast milk, and bone marrow, which are not pluripotent. The church of jesus christ of latter-day article: stem many decades, stem cells have played an important role in medical research, beginning in 1868 when ernst haeckel first used the phrase to describe the fertilized egg which eventually gestates into an organism. Further work by alexander maximow and leroy stevens introduced the concept that stem cells are pluripotent. This has included the many complications inherent in stem cell transplantation (almost 200 allogeneic marrow transplants were performed in humans, with no long-term successes before the first successful treatment was made), through to more modern problems, such as how many cells are sufficient for engraftment of various types of hematopoietic stem cell transplants, whether older patients should undergo transplant therapy, and the role of irradiation-based therapies in preparation for discovery of adult stem cells led scientists to develop an interest in the role of embryonic stem cells, and in separate studies in 1981 gail martin and martin evans derived pluripotent stem cells from the embryos of mice for the first time. This paved the way for mario capecchi, martin evans, and oliver smithies to create the first knockout mouse, ushering in a whole new era of research on human 1998, james thomson and jeffrey jones derived the first human embryonic stem cells, with even greater potential for drug discovery and therapeutic transplantation. However, the use of the technique on human embryos led to more widespread controversy as criticism of the technique now began from the wider non-scientific public who debated the moral ethics of questions concerning research involving human embryonic ial use in therapy[edit]. Pluripotent stem cells have the ability to differentiate into any type of cell, they are used in the development of medical treatments for a wide range of conditions. Yet further treatments using stem cells could potentially be developed due to their ability to repair extensive tissue damage. Only cells from an embryo at the morula stage or earlier are truly totipotent, meaning that they are able to form all cell types including placental cells. Adult stem cells are generally limited to differentiating into different cell types of their tissue of origin. However, some evidence suggests that adult stem cell plasticity may exist, increasing the number of cell types a given adult stem cell can of controversy[edit]. Of the debates surrounding human embryonic stem cells concern issues such as what restrictions should be made on studies using these types of cells. Is it just to destroy an embryo cell if it has the potential to cure countless numbers of patients? Political leaders are debating how to regulate and fund research studies that involve the techniques used to remove the embryo cells. Of the criticism has been a result of religious beliefs, and in the most high-profile case, us president george w bush signed an executive order banning the use of federal funding for any cell lines other than those already in existence, stating at the time, "my position on these issues is shaped by deeply held beliefs," and "i also believe human life is a sacred gift from our creator. I believe we have been given the capacity and will to pursue this research and the humanity and conscience to do so responsibly. Stem cell researchers are working to develop techniques of isolating stem cells that are as potent as embryonic stem cells, but do not require a human st among these was the discovery in august 2006 that adult cells can be reprogrammed into a pluripotent state by the introduction of four specific transcription factors, resulting in induced pluripotent stem cells. An alternative technique, researchers at harvard university, led by kevin eggan and savitri marajh, have transferred the nucleus of a somatic cell into an existing embryonic stem cell, thus creating a new stem cell line. At advanced cell technology, led by robert lanza and travis wahl, reported the successful derivation of a stem cell line using a process similar to preimplantation genetic diagnosis, in which a single blastomere is extracted from a blastocyst. 8] at the 2007 meeting of the international society for stem cell research (isscr),[9] lanza announced that his team had succeeded in producing three new stem cell lines without destroying the parent embryos. These are the first human embryonic cell lines in existence that didn't result from the destruction of an embryo. Atala of wake forest university says that the fluid surrounding the fetus has been found to contain stem cells that, when used correctly, "can be differentiated towards cell types such as fat, bone, muscle, blood vessel, nerve and liver cells". He hopes "that these cells will provide a valuable resource for tissue repair and for engineered organs, as well". Cell debates have motivated and reinvigorated the pro-life movement, whose members are concerned with the rights and status of the embryo as an early-aged human life. They believe that embryonic stem cell research profits from and violates the sanctity of life and is tantamount to murder. 12] the fundamental assertion of those who oppose embryonic stem cell research is the belief that human life is inviolable, combined with the belief that human life begins when a sperm cell fertilizes an egg cell to form a single cell. The view of those in favor is that these embryos would otherwise be discarded, and if used as stem cells, they can survive as a part of a living human being. Portion of stem cell researchers use embryos that were created but not used in in vitro fertility treatments to derive new stem cell lines. 13] this has led some opponents of abortion, such as senator orrin hatch, to support human embryonic stem cell research.
14] see also embryo l researchers widely report that stem cell research has the potential to dramatically alter approaches to understanding and treating diseases, and to alleviate suffering. In the future, most medical researchers anticipate being able to use technologies derived from stem cell research to treat a variety of diseases and impairments. The anticipated medical benefits of stem cell research add urgency to the debates, which has been appealed to by proponents of embryonic stem cell august 2000, the u. The nih believes the potential medical benefits of human pluripotent stem cell technology are compelling and worthy of pursuit in accordance with appropriate ethical standards. 2006, researchers at advanced cell technology of worcester, massachusetts, succeeded in obtaining stem cells from mouse embryos without destroying the embryos. 16] if this technique and its reliability are improved, it would alleviate some of the ethical concerns related to embryonic stem cell r technique announced in 2007 may also defuse the longstanding debate and controversy. Research teams in the united states and japan have developed a simple and cost-effective method of reprogramming human skin cells to function much like embryonic stem cells by introducing artificial viruses. While extracting and cloning stem cells is complex and extremely expensive, the newly discovered method of reprogramming cells is much cheaper. However, the technique may disrupt the dna in the new stem cells, resulting in damaged and cancerous tissue. 21][22] the planned treatment trials will focus on the effects of oral lithium on neurological function in people with chronic spinal cord injury and those who have received umbilical cord blood mononuclear cell transplants to the spinal cord. The interest in these two treatments derives from recent reports indicating that umbilical cord blood stem cells may be beneficial for spinal cord injury and that lithium may promote regeneration and recovery of function after spinal cord injury. Both lithium and umbilical cord blood are widely available therapies that have long been used to treat diseases in nic stem cells have the potential to grow indefinitely in a laboratory environment and can differentiate into almost all types of bodily tissue. This makes embryonic stem cells a prospect for cellular therapies to treat a wide range of diseases. 24][25] thus, far more embryos are lost due to chance than are proposed to be used for embryonic stem cell research or cysts are a cluster of human cells that have not differentiated into distinct organ tissue, making cells of the inner cell mass no more "human" than a skin cell. The destruction of human embryos is required to establish a stem cell line, no new embryos have to be destroyed to work with existing stem cell lines. It would be wasteful not to continue to make use of these cell lines as a resource. Is usually presented as a counter-argument to using adult stem cells as an alternative that does not involve embryonic nic stem cells make up a significant proportion of a developing embryo, while adult stem cells exist as minor populations within a mature individual (e. In every 1,000 cells of the bone marrow, only one will be a usable stem cell). Thus, embryonic stem cells are likely to be easier to isolate and grow ex vivo than adult stem cells. Stem cells divide more rapidly than adult stem cells, potentially making it easier to generate large numbers of cells for therapeutic means. Stem cells have greater plasticity, potentially allowing them to treat a wider range of diseases. Stem cells from the patient's own body might not be effective in treatment of genetic disorders. From a healthy donor) may be more practical in these cases than gene therapy of a patient's own cell. Abnormalities found in adult stem cells that are caused by toxins and sunlight may make them poorly suited for treatment. Stem cells have the potential to cure chronic and degenerative diseases which current medicine has been unable to effectively the primitive streak is formed when the embryo attaches to the uterus around 14 days after fertilization, two fertilized eggs can combine by fusing together and develop into one person (a tetragametic chimera). Those who subscribe to this belief then hold that destroying a blastocyst for embryonic stem cells is ethical. Embryos used in medical research for stem cells are well below development that would enable argument is used by opponents of embryonic destruction, as well as researchers specializing in adult stem cell -life supporters often claim that the use of adult stem cells from sources such as the umbilical cord blood has consistently produced more promising results than the use of embryonic stem cells. 30] furthermore, adult stem cell research may be able to make greater advances if less money and resources were channeled into embryonic stem cell research. 31] stem cell research is highly frowned upon in many ethnic and religious the past, it has been a necessity to research embryonic stem cells and in doing so destroy them for research to progress. 32] as a result of the research done with both embryonic and adult stem cells, new techniques may make the necessity for embryonic cell research obsolete. Because many of the restrictions placed on stem cell research have been based on moral dilemmas surrounding the use of embryonic cells, there will likely be rapid advancement in the field as the techniques that created those issues are becoming less of a necessity.
33] many funding and research restrictions on embryonic cell research will not impact research on ipscs (induced pluripotent stem cells) allowing for a promising portion of the field of research to continue relatively unhindered by the ethical issues of embryonic research. Stem cells have provided many different therapies for illnesses such as parkinson's disease, leukemia, multiple sclerosis, lupus, sickle-cell anemia, and heart damage[35] (to date, embryonic stem cells have also been used in treatment),[36] moreover, there have been many advances in adult stem cell research, including a recent study where pluripotent adult stem cells were manufactured from differentiated fibroblast by the addition of specific transcription factors. 37] newly created stem cells were developed into an embryo and were integrated into newborn mouse tissues, analogous to the properties of embryonic stem views of groups[edit]. Denmark, france, germany, portugal and ireland do not allow the production of embryonic stem cell lines,[38] but the creation of embryonic stem cell lines is permitted in finland, greece, the netherlands, sweden, and the united kingdom. These developments prompted the federal government to create regulations barring the use of federal funds for research that experimented on human embryos. In 1995, the nih human embryo research panel advised the administration of president bill clinton to permit federal funding for research on embryos left over from in vitro fertility treatments and also recommended federal funding of research on embryos specifically created for experimentation. In response to the panel's recommendations, the clinton administration, citing moral and ethical concerns, declined to fund research on embryos created solely for research purposes,[39] but did agree to fund research on leftover embryos created by in vitro fertility treatments. At this point, the congress intervened and passed the dickey amendment in 1995 (the final bill, which included the dickey amendment, was signed into law by bill clinton) which prohibited any federal funding for the department of health and human services be used for research that resulted in the destruction of an embryo regardless of the source of that 1998, privately funded research led to the breakthrough discovery of human embryonic stem cells (hesc). Though embryo destruction had been inevitable in the process of harvesting hesc in the past (this is no longer the case[41][42][43][44]), the clinton administration had decided that it would be permissible under the dickey amendment to fund hesc research as long as such research did not itself directly cause the destruction of an embryo. Bush administration which decided to reconsider the ent bush announced, on august 9, 2001, that federal funds, for the first time, would be made available for hesc research on currently existing embryonic stem cell lines. President bush authorized research on existing human embryonic stem cell lines, not on human embryos under a specific, unrealistic timeline in which the stem cell lines must have been developed. However, the bush administration chose not to permit taxpayer funding for research on hesc cell lines not currently in existence, thus limiting federal funding to research in which "the life-and-death decision has already been made". Both the bush and clinton guidelines agree that the federal government should not fund hesc research that directly destroys r congress nor any administration has ever prohibited private funding of embryonic research. Public and private funding of research on adult and cord blood stem cells is unrestricted. April 2004, 206 members of congress signed a letter urging president bush to expand federal funding of embryonic stem cell research beyond what bush had already may 2005, the house of representatives voted 238–194 to loosen the limitations on federally funded embryonic stem-cell research—by allowing government-funded research on surplus frozen embryos from in vitro fertilization clinics to be used for stem cell research with the permission of donors—despite bush's promise to veto the bill if passed. Frist (r-tn), announced that he too favored loosening restrictions on federal funding of embryonic stem cell research. The senate passed the first bill (the stem cell research enhancement act) 63–37, which would have made it legal for the federal government to spend federal money on embryonic stem cell research that uses embryos left over from in vitro fertilization procedures. The second bill makes it illegal to create, grow, and abort fetuses for research purposes. Embryonic-like, stem cells without the destruction of human 2005 and 2007, congressman ron paul introduced the cures can be found act,[49] with 10 cosponsors. With an income tax credit, the bill favors research upon non–embryonic stem cells obtained from placentas, umbilical cord blood, amniotic fluid, humans after birth, or unborn human offspring who died of natural causes; the bill was referred to committee. Paul argued that hesc research is outside of federal jurisdiction either to ban or to subsidize. Vetoed another bill, the stem cell research enhancement act of 2007,[51] which would have amended the public health service act to provide for human embryonic stem cell research. 53] two days after obama removed the restriction, the president then signed the omnibus appropriations act of 2009, which still contained the long-standing dickey-wicker provision which bans federal funding of "research in which a human embryo or embryos are destroyed, discarded, or knowingly subjected to risk of injury or death;"[54] the congressional provision effectively prevents federal funding being used to create new stem cell lines by many of the known methods. So, while scientists might not be free to create new lines with federal funding, president obama's policy allows the potential of applying for such funding into research involving the hundreds of existing stem cell lines as well as any further lines created using private funds or state-level funding. The ability to apply for federal funding for stem cell lines created in the private sector is a significant expansion of options over the limits imposed by president bush, who restricted funding to the 21 viable stem cell lines that were created before he announced his decision in 2001. 55] the ethical concerns raised during clinton's time in office continue to restrict hesc research and dozens of stem cell lines have been excluded from funding, now by judgment of an administrative office rather than presidential or legislative discretion. 2005, the nih funded $607 million worth of stem cell research, of which $39 million was specifically used for hesc. 57] sigrid fry-revere has argued that private organizations, not the federal government, should provide funding for stem-cell research, so that shifts in public opinion and government policy would not bring valuable scientific research to a grinding halt. 2005, the state of california took out $3 billion in bond loans to fund embryonic stem cell research in that state. In the absence of a public controversy, human embryo stem cell research is supported by policies that allow the use of human embryos and therapeutic cloning. To rabbi levi yitzchak halperin of the institute for science and jewish law in jerusalem, embryonic stem cell research is permitted so long as it has not been implanted in the womb.
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Not only is it permitted, but research is encouraged, rather than wasting long as it has not been implanted in the womb and it is still a frozen fertilized egg, it does not have the status of an embryo at all and there is no prohibition to destroy it... The best and worthiest solution is to use it for life-saving purposes, such as for the treatment of people that suffered trauma to their nervous system, etc. 3, 2:rly, the sole jewish majority state, israel, permits research on embryonic stem catholic church opposes human embryonic stem cell research calling it "an absolutely unacceptable act. The church supports research that involves stem cells from adult tissues and the umbilical cord, as it "involves no harm to human beings at any state of development. Southern baptist convention opposes human embryonic stem cell research on the grounds that "bible teaches that human beings are made in the image and likeness of god (gen. 62] however, it supports adult stem cell research as it does "not require the destruction of embryos. United methodist church opposes human embryonic stem cell research, saying, "a human embryo, even at its earliest stages, commands our reverence. 63] however, it supports adult stem cell research, stating that there are "few moral questions" raised by this issue. Assemblies of god opposes human embryonic stem cell research, saying, it "perpetuates the evil of abortion and should be prohibited. Religion of islam favors the stance that scientific research and development in terms of stem cell research is allowed as long as it benefits society while using the least amount of harm to the subjects. Stem cell research is one of the most controversial topics of our time period and has raised many religious and ethical questions regarding the research being done. One of the teachings of the qur'an states that “whosoever saves the life of one, it shall be if he saves the life of humankind” (5:32), it is this teaching that makes stem cell research acceptable in the muslim faith because of its promise of potential medical breakthrough. First presidency of the church of jesus christ of latter-day saints "has not taken a position regarding the use of embryonic stem cells for research purposes. The absence of a position should not be interpreted as support for or opposition to any other statement made by church members, whether they are for or against embryonic stem cell research. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors". The stated reason for president bush's objection to embryonic stem cell research is that 'murder is wrong'" (bbc). A b c d e f g h i j k "arguments for stem cell research". This frees biologists to work with a wide range of human escs—including cell lines created with state and private funding. But researchers are not expected to be able to use federal grants to create new cell lines. Statement from the director on the addition of new lines to the human embryonic stem cell registry" nih, june 21, 2010. Retrieved : the stem cell controversy january 18, 2006, woodrow wilson center event featuring robin cook (novelist), william b. By sigrid the personhood of pre-implantation about stem cell ethics and d pluripotent stem itor cell: endothelial stem poietic stem hymal stem ar cell cell laws and policy in the united etics in stem cell ries: stem cellsmedical controversiesethically disputed practiceshidden categories: webarchive template wayback linksarticles with attributed pull logged intalkcontributionscreate accountlog pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia out wikipediacommunity portalrecent changescontact links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this a bookdownload as pdfprintable page was last edited on 6 november 2017, at 19: is available under the creative commons attribution-sharealike license;. A non-profit cell wikipedia, the free to: navigation, stem cell controversy is the consideration of the ethics of research involving the development, use, and destruction of human embryos. 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This free service is available to anyone who has published and whose publication is in es in biological pmental an journal of cell mental cell expression isms of rs in cell and developmental international journal of biochemistry & cell cell research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to stem cell research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancerstem cells, developmental studies... Cell research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to stem cell research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancerstem cells, developmental studies, genomics and translational research. Special focus of scr is on mechanisms of pluripotency and description of newly generated pluripotent stem cell journal publishes• original articles• short reports• review articles• communications• methods and reagents articles• lab resource: stem cell linestem cell research currently has a time to first decision of less than 4 weeks; and over 420,000 downloads in full aims & embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial effect of low-frequency electromagnetic field on human bone marrow stem/progenitor cell cell treatment of degenerative eye d pluripotent stem cells derived from an autosomal dominant polycystic kidney disease patient carrying a pkd1 q533x mutation. Human ips cell myogenic differentiation system permitting high-throughput drug ed human somatic cell reprogramming efficiency by fusion of the myc transactivation domain and contribution of human/non-human animal chimeras to stem cell otency of embryo-derived stem cells from rodents, lagomorphs, and primates: slippery slope, terrace and ages of nonhuman primates as preclinical models for evaluating stem cell-based therapies for parkinson's regeneration and downloaded most downloaded articles from stem cell research in the last 90 embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial effect of low-frequency electromagnetic field on human bone marrow stem/progenitor cell cell treatment of degenerative eye ly published articles from stem cell d pluripotent stem cells derived from an autosomal dominant polycystic kidney disease patient carrying a pkd1 q533x mutation. Human ips cell myogenic differentiation system permitting high-throughput drug ed human somatic cell reprogramming efficiency by fusion of the myc transactivation domain and ly published review articles from stem cell research review contribution of human/non-human animal chimeras to stem cell otency of embryo-derived stem cells from rodents, lagomorphs, and primates: slippery slope, terrace and ages of nonhuman primates as preclinical models for evaluating stem cell-based therapies for parkinson's l issues published in stem cell regeneration and n partner journal is now partnering with heliyon, an open access journal from elsevier publishing quality peer reviewed research across all disciplines.
Partner journals provide authors with an easy route to transfer their research to for papers "integrative biology studies in pluripotent stem cells". Deadline 31st december l issues and l issue in preparation: germline stem cells and germ lineage edited by kyle orwig and amander out our online page! Resource template for multiple related pluripotent stem cell resources: 2017 starts with a new editor, template and e to sunita d'souza and updated requirements for new article type to describe and publish newly generated pluripotent stem cell your lab resource ad templates and learn how to submit lab resource ific guidelines for lab hed lab metrics – top social media is a recent list of 2017 articles that have had the most social media attention. Go here to learn more about plumx tion and characterization of a human induced pluripotent stem (ips) cell line derived from an acute myeloid leukemia patient evolving from primary myelofibrosis carrying the calr 52bp deletion and the asxl1 p. Generation and characterization of a human induced pluripotent stem (ips) cell line derived from an acute myeloid leukemia patient evolving from primary myelofibrosis carrying the calr 52bp deletion and the asxl1 p. Lytic processed form of cxcl12 abolishes migration and induces apoptosis in neural stem cells in vitro. Proteolytic processed form of cxcl12 abolishes migration and induces apoptosis in neural stem cells in integration-free, virus-free rhesus macaque induced pluripotent stem cell line (ripsc90) from embryonic fibroblasts. An integration-free, virus-free rhesus macaque induced pluripotent stem cell line (ripsc90) from embryonic note that internet explorer version 8. Please enable javascript to use all the features on this cell researchvolume 25, in progressvolume / issue in progressa volume/issue that is "in progress" contains final, fully citable articles that are published online, but the volume/issue itself is awaiting more articles before it can be considered "final". For recently accepted articles, see articles in ch paperschromosome copy number variation in telomerized human bone marrow stromal cells; insights for monitoring safe ex-vivo expansion of adult stem cellsoriginal research articlepages 6-17jorge s. Novel neoplastic risk biomarkers may enhance autologous/allogeneic hbmsc access open access article short communicationa human ips cell myogenic differentiation system permitting high-throughput drug screeningpages 98-106tomoya uchimura, jun otomo, masae sato, hidetoshi sakuraiabstractclose research highlights pdf (2185 k). Establishment of feeder-free myogenic differentiation of human ips cells•fluorescent-tag free ipsc myogenic differentiation culture•reliable myogenic differentiation of human ips cells by replating technique•adaptation of feeder-free culture system to screening compatible plateopen access open access article research papersmurine pluripotent stem cells with a homozygous knockout of foxg1 show reduced differentiation towards cortical progenitors in vitrooriginal research articlepages 50-60eva maria mall, doris herrmann, heiner niemannabstractclose research highlights pdf (2773 k). Contenthighlights•foxg1 knockout can be recapitulated with simple neuronal differentiation protocol•pluripotent stem cells with foxg1 knockout form embryoid body like structures expressing reduced levels of cortical genes•neuronal differentiation using embryoid body like structures is a versatile tool to study defects that are lethal in vivoopen access open access article short communicationsubstrate and mechanotransduction influence serca2a localization in human pluripotent stem cell-derived cardiomyocytes affecting functional performancepages 107-114sebastian martewicz, elena serena, susi zatti, gordon keller, nicola elvassoreabstractclose research highlights pdf (1763 k). Mechanotransduction through rock activity is involved in structural access open access article research paperslung regeneration after toxic injury is improved in absence of dioxin receptororiginal research articlepages 61-71antonio morales-hernández, ana nacarino-palma, nuria moreno-marín, eva barrasa, beroé paniagua-quiñones, inmaculada catalina-fernández, alberto alvarez-barrientos, xosé r. Access open access article research paperscomparative performance analysis of human ipsc-derived and primary neural progenitor cells (npc) grown as neurospheres in vitrooriginal research articlepages 72-82maxi hofrichter, laura nimtz, julia tigges, yaschar kabiri, friederike schröter, brigitte royer-pokora, barbara hildebrandt, martin schmuck, alexey epanchintsev, stephan theiss, james adjaye, jean-marc egly, jean krutmann, ellen fritscheabstractclose research highlights pdf (3052 k). Adverse effects of the developmentally neurotoxic compound mehgcl on cell migrationopen access open access article research papersenhanced human somatic cell reprogramming efficiency by fusion of the myc transactivation domain and oct4original research articlepages 88-97ling wang, delun huang, chang huang, yexuan yin, kaneha vali, ming zhang, young tangabstractclose research highlights pdf (2807 k). Contenthighlights•fusion of myc transactivation domain with oct4 (myc-tad-oct4) shortens the dynamics of mouse and human cell reprogramming•myc-tad-oct4 protein greatly enhances human cell reprogramming efficiency•myc box ii and the linker between myc box1/ii are necessary for the enhanced reprogramming activity of myc-tad-oct4 proteinopen access open access article lab resourcesintegration-free induced pluripotent stem cells derived from a patient with autosomal recessive alport syndrome (aras)pages 1-5bernd kuebler, begoña aran, laia miquel-serra, yolanda muñoz, elisabet ars, gemma bullich, monica furlano, roser torra, merce marti, anna veiga, angel rayaabstract pdf (1861 k). Contentopen access open access article lab resourcesderivation and characterization of integration-free ipsc line isrm-um51 derived from six2-positive renal cells isolated from urine of an african male expressing the cyp2d6 *4/*17 variant which confers intermediate drug metabolizing activitypages 18-21martina bohndorf, audrey ncube, lucas-sebastian spitzhorn, jürgen enczmann, wasco wruck, james adjayeabstract pdf (1259 k). Contentopen access open access article lab resourcesgeneration of a human control pbmc derived ips cell line tusmi001-a from a healthy male donor of han chinese genetic backgroundpages 22-25ying wang, yue zhang, jing zhang, jing lu, chaowen yang, jian zhao, gang li, zhongmin liu, ying leiabstract pdf (1092 k). Contentopen access open access article establishment of an induced pluripotent stem (ips) cell line from dermal fibroblasts of an asymptomatic patient with dominant prpf31 mutationpages 26-29angélique terray, victoire fort, amélie slembrouck, céline nanteau, josé-alain sahel, sacha reichman, isabelle audo, olivier goureauabstract pdf (1651 k). Access open access article research paperslocal angiotensin ii promotes adipogenic differentiation of human adipose tissue mesenchymal stem cells through type 2 angiotensin receptororiginal research articlepages 115-122veronika y. Endogenous angii triggers adsc adipose competency via at2 access open access article lab resourcesgeneration of human erythroblast-derived ipsc line using episomal reprogramming systempages 30-33eszter varga, marten hansen, tatjana wüst, marieke von lindern, emile van den akkerabstract pdf (1047 k). Access open access article lab resourcesgeneration of an induced pluripotent stem cell line, ibms-ipsc-014-05, from a female autosomal dominant polycystic kidney disease patient carrying a common mutation of r803x in pkd2pages 38-41ming-ching ho, ching-ying huang, jia-jung lee, shih-han hsu, yu-che cheng, yu-hung hsu, daw-yang hwang, huai-en lu, hung-chun chen, patrick c. Contentopen access open access article lab resourcesgeneration of two induced pluripotent stem cell (ipsc) lines from x-linked adrenoleukodystrophy (x-ald) patients with adrenomyeloneuropathy (amn)pages 46-49daryeon son, zhejiu quan, phil jun kang, gyuman park, hoon-chul kang, seungkwon youabstract pdf (754 k). Contentopen access open access article induced pluripotent stem cells derived from an autosomal dominant polycystic kidney disease patient carrying a pkd1 q533x mutationpages 83-87jia-jung lee, ming-ching ho, ching-ying huang, cheng-hao wen, yu-che cheng, yu-hung hsu, daw-yang hwang, huai-en lu, hung-chun chen, patrick c. Sciencedirect ® is a registered trademark of elsevier president writes in support of fetal tissue an opinion editorial published today, the president of the isscr, hans clevers, underscores the importance of fetal tissue research. Fetal tissue has been essential in research used to develop therapies that have saved millions of lives, and it continues to be necessary for the future of medicine,” he applauds california bill to assist stem cell patients. Requires clinics to inform patients if they are using stem cell interventions that have not been approved by the food and drug administration (fda). Stem cells: the next generation," guangzhou, china international symposium20 june, 2018-24 june, 2018, melbourneisscr 2018 annual meeting, melbourne, up to receive the newsletter or make your organization known to 20,000 readers by advertising in the pulse! The resources and connections you further drive your career and skills in ng field of stem cell r you are a job seeker or employer, the isscr job board is the best place to find and post jobs in the stem cell science you join the isscr, you become part largest and most renowned stem cell rative medicine community in the , car-t, and chers around the world have long sought effective treatments for cancer, and are now seeing therapeutic benefit with a new treatment, which is demonstrating better than imagined success in patients with blood ndent nonprofit organization & the voice of the stem cell research international society for stem cell research (isscr) is an independent nonprofit organization and the voice of the stem cell research community. 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The isscr provides a platform for professional and public education and the promotion of rigorous scientific and ethical standards in stem cell research and regenerative visit our affiliated journals, cell stem cell and current protocols in stem cell biology, included in professional ion of retinal pigment epithelium-specific antibody in ipsc-derived retinal pigment epithelium transplantation entiation of human induced pluripotent or embryonic stem cells decreases the dna damage repair by homologous mole rat cells have a stable epigenome that resists ipsc reprogramming.