Nih research plan
Contracts > apply for a grant > prepare your your research planin this part, we give you detailed information about writing an effective research plan. We start with the importance and parameters of significance and then discuss how to focus the research plan, relying on the iterative process described in the iterative approach to application planning checklist shown at draft specific aims and give you advice for filling out the 'll also learn the importance of having a well-organized, visually appealing application that avoids common missteps and the importance of preparing your just-in-time information this document is geared toward the basic research project grant, the r01, much of it is useful for other grant ch plan overview and your ch strategy for a successful research icance, innovation, and ng for your inary studies or progress ncing and finalize your research ct and ch plan overview and your application's research plan has two sections:Specific aims—a one-page statement of your objectives for the ch strategy—a description of the rationale for your research and your experiments in 12 pages for an your specific aims, you note the significance and innovation of your research; then list your two to three concrete objectives, your research strategy is the nuts and bolts of your application, where you describe your research rationale and the experiments you will conduct to accomplish each aim. Though how you organize it is largely up to you, nih expects you to follow these ze using bold headers or an outline or numbering system—or both—that you use consistently each section with the appropriate header: significance, innovation, or ze the approach section around your specific of your research write the research plan, you don't need the application forms. Read the instructions at nih’s format an r01, the research strategy can be up to 12 pages, plus one page for specific aims. Nih is on the lookout and may return your application to you if you try to evade page you read this page, look at our sample applications and more to see some of the different strategies successful pis use to create an outstanding research g it all in g in a logical sequence will save you ation you put in the research plan affects just about every other application part. You'll need to keep everything in sync as your plans evolve during the writing 's best to consider your writing as an iterative process. We suggest proceeding in the following order:Create a provisional a draft of your specific your research with your significance and innovation draft the approach section considering the personnel and skills you'll need for each te your specific aims and methods in light of your expected budget (for a new pi, it should be modest, probably under the $250,000 for nih's modular budget). There are many ways to create a great application, so explore your the character limit, include the important information to distinguish your project within the research area, your project's goals, and the research your project a title at the outset can help you stay focused and avoid a meandering research plan. Instead, we advise you to keep the title as succinct as possible while including the important information to distinguish your project within the research area. Make your title specific: saying you are studying lymphocyte trafficking is not informative examples of strong titles, see our sample applications and you write a preliminary title, check title is specific, indicating at least the research area and the goals of my is 200 characters or less. That's fine—at this point, it's just an aid to keep your plans all your reviewers read your specific aims, you want to excite them about your testing your hypothesis is the destination for your research, your research plan is the map that takes you 'll start by writing the smaller part, the specific aims. Since all your reviewers read your specific aims, you want to excite them about your more on crafting your specific aims, see draft specific at least half the page to provide the rationale and significance of your planned research. A good way to start is with a sentence that states your project's the rest of the narrative, you will describe the significance of your research, and give your rationale for choosing the project. In some cases, you may want to explain why you did not take an alternative , briefly describe your aims, and show how they build on your preliminary studies and your previous research. State your it is likely your application will be reviewed by a study section with broad expertise, summarize the status of research in your field and explain how your project fits the narrative part of the specific aims of many outstanding applications, people also used their aims the technologies they plan to their expertise to do a specific task or that of be past accomplishments related to the be preliminary studies and new and highly relevant findings in the n their area's how the aims relate to one be expected outcomes for each n how they plan to interpret data from the aim’s be how to address potential pitfalls with contingency ing on your situation, decide which items are important for you. For example, a new investigator would likely want to highlight preliminary data and qualifications to do the people use bold or italics to emphasize items they want to bring to the reviewers' attention, such as the hypothesis or the narrative, enter your aims as bold bullets, or stand-alone or run-on your plans using strong verbs like identify, define, quantify, establish, be each aim in one to three er adding bullets under each aim to refine your focused should your aims be? Keep to the one-page of my two or three aims is a narrowly focused, concrete objective i can achieve during the aims highlight the significance of the research to science and give a clear picture of how my project can generate knowledge that may improve human show my project's importance to science, how it addresses a critical research opportunity that can move my field text states how my work is innovative. Each element listed above, analyze your text and revise it until your specific aims hit all the key points you'd like to the list of aims, some people add a closing paragraph, emphasizing the significance of the work, their collaborators, or whatever else they want to focus reviewers' attention ch strategy research strategy is the bigger part of your application's research plan (the other part is the specific aims—discussed above. Research strategy is the nuts and bolts of your application, describing the rationale for your research and the experiments you will do to accomplish each aim. How you organize your application is largely up to you, nih does want you to follow these guidelines:Add bold headers or an outlining or numbering system—or both—that you use consistently each of the research strategy's sections with a header: significance, innovation, and ze the approach section around your specific an r01, the research strategy is limited to 12 pages for the three main sections and the preliminary studies only. The requirement applies to research grant, career development, fellowship, and training you're responding to an institute-specific program announcement (pa) (not a parent program announcement) or a request for applications (rfa), check the nih guide notice, which has additional information you need. Niaid program staff will check your application, and if it is not responsive to the announcement, your application will be returned to you without a for a successful research writing your research strategy, your goal is to present a well-organized, visually appealing, and readable description of your proposed project. If writing is not your forte, get are many ways to create an outstanding research plan, so explore your success looks application's research plan is the map that shows your reviewers how you plan to test your not only lays out your experiments and expected outcomes, but must also convince your reviewers of your likely success by allaying any doubts that may cross their minds that you will be able to conduct the in the sample applications how the writing keeps reviewers' eyes on the ball by bringing them back to the main points the pis want to make. When reviewers read your application, they'll look for the answers to three basic questions:Can your research move your field forward?
They don't stop at the significance section to emphasize their project's importance, and they look beyond their biosketches to highlight their team's 't take a chance your reviewer will gloss over that one critical sentence buried somewhere in your research strategy or elsewhere. Are more strategies from our successful pis:While describing a method in the approach section, they state their or collaborators' experience with point out that they have access to a necessary piece of explaining their field and the status of current research, they weave in their own work and their preliminary delve into the biology of the area to make sure reviewers will grasp the importance of their research and understand their field and how their work fits into can see many of these principles at work in the approach section of the application from dr. Felt that the experiments described for aim 1 will yield clear plans to translate those findings to gene targets of relevance are well outlined and ties his proposed experiments to the larger picture, including past research and strong preliminary data for the current pate reviewer applicants not only wrote with their reviewers in mind they seemed to anticipate their questions. These questions; then spend time thinking about more potential issues specific to you and your research—and address those applications, a picture can truly be worth a thousand words. Graphics can illustrate complex information in a small space and add visual interest to your at our sample applications to see how the investigators included schematics, tables, illustrations, graphs, and other types of graphics to enhance their er adding a timetable or flowchart to illustrate your experimental plan, including decision trees with alternative experimental pathways to help your reviewers understand your you plan to send one or more videos, you'll need to meet certain standards and include key information in your research strategy present some concepts or demonstrations, video may enhance your application beyond what graphics alone can achieve. Help your cause by taking the following steps:Caption any narration in the the research strategy:choose evocative still images from your video to accompany your your summary of the video carefully so the text would make sense even without the addition to those considerations, create your videos to fit nih’s technical requirements. Learn more in the sf 424 form , as you write your research strategy, include key images from the video and a brief , state in your cover letter that you plan to send video later. While you want to be organized, how you go about it is up to heless, here are some principles to follow:Add bold headers or an outlining or numbering system—or both—that you use consistently each of the research strategy's sections with a header: significance, innovation, and approach—this you must ze the approach section around your specific research strategy's page limit—12 for r01s—is for the three main parts: significance, innovation, and approach and your preliminary studies (or a progress report if you're renewing your grant). Other sections, for example, research animals or select agents, do not have a page icance, innovation, and gh you will emphasize your project's significance throughout the application, the significance section should give the most details. Don't skimp—the farther removed your reviewers are from your field, the more information you'll need to provide on basic biology, importance of the area, research opportunities, and new you describe your project's significance, put it in the context of 1) the state of your field, 2) your long-term research plans, and 3) your preliminary our sample applications, you can see that both investigators and reviewers made a case for the importance of the research to improving human health as well as to the scientific at the significance section of the application from dr. Jiang starts with a summary of the field of polyomavirus research, identifying critical knowledge gaps in the application ties the lab's previous discoveries and new research plans to filling those gaps, establishing the significance with the use of formatting, whitespace, and sectioning to highlight key points and make it easier for reviewers to read the conveying the significance of the research in several parts of the application, check the significance section, i describe the importance of my hypothesis to the field (especially if my reviewers are not in it) and human disease. Also point out the project's significance throughout the application shows that i am aware of opportunities, gaps, roadblocks, and research underway in my field. State how my research will advance my field, highlighting knowledge gaps and showing how my project fills one or more of on my scan of the review committee roster, i determine whether i cannot assume my reviewers will know my field and provide some information on basic biology, the importance of the area, knowledge gaps, and new you are either a new pi or entering a new area: be cautious about seeming too innovative. Explores new scientific avenues, has a novel hypothesis, will create new i am a new investigator:most likely, i explain how my project's research can refine, improve, or propose a new application of an existing concept or likely, i go for the other option described in nih's definition: show how my research can shift a current paradigm. Though people generally used less detail than you'd see in a scientific paper, they do include some experimental your assigned reviewers to scrutinize your approach: they will want to know what you plan to do and how you plan to do data show that of the peer review criteria, approach has the highest correlation with the overall impact at the application from dr. For experiments that are pedestrian or contracted out, just list the sure to lay out a plan for alternative experiments and approaches in case you get negative or surprising results. Show reviewers you have a plan for spending the four or five years you will be funded no matter where the experiments the application from drs. I reviewed the sample applications to see how much detail to is clear what i do well and what unique skills i and my team bring to the research. Here's where you build reviewer confidence that you are headed in the right direction by pursuing research that builds on your ers use your preliminary studies together with the biosketches to assess the investigator review criterion, which reflects the competence of the research alternative interpretations to your data to show reviewers you've thought through problems in-depth and are prepared to meet future challenges. You may include other people's publications, focus on your preliminary data or unpublished data from your lab and the labs of your team members as much as you we noted above, you can put your preliminary data anywhere in the research strategy that you feel is appropriate, but just make sure your reviewers will be able to distinguish it. If you leave out an important work, reviewers may assume you're not aware of hout your application, you will reference all relevant publications for the concepts underlying your research and your more about your bibliography and references cited at add a bibliography and finishing the draft, check hout my application i cite the literature thoroughly but not excessively, adding citations for all references important to my work. Refer to unpublished work, including information i learned through personal i do not describe a method, i add a reference to the and finalize your research over what you've written with a critical eye of a reviewer to identify potential questions or weak others to do that too—they can look at your application with a fresh eye. Include people who aren't familiar with your research to make sure you can get your point across to someone outside your you finalize the details of your research strategy, you will also need to return to your specific aims to see if you must revise. See draft specific ct and you finish your research plan, you are ready to write your abstract (called project summary/abstract) and project narrative, which are attachments to the other project information sections may be small, but they're your peer reviewers read your abstract and and automated systems in nih's center for scientific review use them to decide where to assign your application, even if you requested an institute and study show the importance and health relevance of your research to members of the public and congress who are interested in what nih is funding with taxpayer sure to omit confidential or proprietary information in these sections!
Your specific aims as a template—shorten it and simplify the the first sentence, state the significance of your research to your field and relevance to niaid's mission: to better understand, treat, and prevent infectious, immunologic, and allergic state your hypothesis and the innovative potential of your list and briefly describe your specific aims and long-term your project narrative, you have only a few sentences to drive home your project's potential to improve public out these effective abstracts and narratives from our r01 sample applications:Application from dr. Step: know your audiencenext step: plan your budget & ist: my project summary/abstract and project narrative (and title) are accessible to a broad describe the significance of my research to my field and state my hypothesis, my aims, and the innovative potential of my narrative describes my project's potential to improve public health. Program officer in your area of science can give you application advice, niaid's perspective on your research, and confirmation that niaid will accept your contacts and instructions at when to contact a niaid program t last reviewed on september 28, ad general instructions - l application guide for nih and other phs 424 (r&r) - forms version d released: march 24, 2017. 400 - phs 398 research plan phs 398 research plan form is used only for research, multi-project, and sbir/sttr form includes fields to upload several attachments, including the specific aims and research research plan should include sufficient information needed for evaluation of the project, independent of any other document (e. Be specific and informative, and avoid ch plan subjects research plan application should represent a sound approach to the investigation of an important biomedical research, behavioral research, technological, engineering, or scientific question, and be worthy of support under the stated criteria of the foa. The scientific and technical merit of the proposed research is the primary concern for all research supported by the national institutes of health (nih) and other phs all the instructions in the foa before completing this form to ensure that your application meets all ic-specific should use the phs 398 research plan form:Use the phs 398 research plan form only if you are submitting a research, multi-project, or sbir/sttr onal instructions for sbir/sttr:You are strongly encouraged to contact agency program staff for pre-application guidance and/or for more specific information on the research topics described in the applicant small business must not propose market research, patent applications, or litigation. The research proposed in this application may, however, be carried out through construction and evaluation of a laboratory prototype, where to all commercialization readiness pilot (crp) program applications:Crp uses sbir funding, but is not a phase i/ii/iib or fast-track application. Although the "introduction" attachment is optional, you may get a system warning if there is no ch plan must complete the "specific aims" attachment:The "specific aims" attachment is required unless otherwise specified in the the page limits for the specific aims in the nih table of page limits unless otherwise specified in the this information as a pdf file. See nih's format attachments concisely the goals of the proposed research and summarize the expected outcome(s), including the impact that the results of the proposed research will have on the research field(s) succinctly the specific objectives of the research proposed (e. Instructions for multi-project:Overall component: the "specific aims" attachment is components: the "specific aims" attachment is onal instructions for sbir/sttr:Phase i applications: state the specific objectives of the phase i research and development effort, including the technical questions you will try to answer to determine the phase i feasibility of the proposed approach and the impact that the results of the proposed research will exert on the research field(s) involved. State concisely and realistically what the proposed research is intended to accomplish in terms of its potential for technological innovation and commercial application. Include milestones for each of the aims as these will be used in the evaluation ii, phase iib, and crp applications: state the specific objectives of the phase ii research and development effort including the impact that the results of the proposed research will exert on the research field(s). Note that the page limit applies to both phases in combination, not to each phase must complete the "research strategy" attachment:The "research strategy" attachment is the page limits for the research strategy in the nih table of page limits, unless otherwise specified in the foa. Although multiple sections of information are required in the research strategy as detailed below, the page limit applies to the entirety of the single "research strategy" this information as a pdf file. See nih's format attachments ze the research strategy in the specified order and use the instructions provided below unless otherwise specified in the foa. Start each section with the appropriate heading - significance, innovation, published experimental details in the research strategy attachment and provide the full reference in g. R&r other project information form, bibliography and reference n the importance of the problem or critical barrier to progress that the proposed project be the scientific premise for the proposed project, including consideration of the strengths and weaknesses of published research or preliminary data crucial to the support of your n how the proposed project will improve scientific knowledge, technical capability, and/or clinical practice in one or more broad onal instructions for research:Describe how the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field will be changed if the proposed aims are onal instructions for multi-project:Overall and other components: describe how the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field will be changed if the proposed aims are onal instructions for sbir/sttr:Explain the project's potential to lead to a marketable product, process, or ii, crp, fast-track, and phase iib competing renewals: explain how the commercialization plan demonstrates a high probability of n how the application challenges and seeks to shift current research or clinical practice be any novel theoretical concepts, approaches or methodologies, instrumentation or interventions to be developed or used, and any advantage over existing methodologies, instrumentation, or n any refinements, improvements, or new applications of theoretical concepts, approaches or methodologies, instrumentation, or be the overall strategy, methodology, and analyses to be used to accomplish the specific aims of the project. Unless addressed separately in the resource sharing plan, include how the data will be collected, analyzed, and interpreted, as well as any resource sharing plans as s potential problems, alternative strategies, and benchmarks for success anticipated to achieve the the project is in the early stages of development, describe any strategy to establish feasibility, and address the management of any high risk aspects of the proposed n how relevant biological variables, such as sex, are factored into research designs and analyses for studies in vertebrate animals and humans. For example, strong justification from the scientific literature, preliminary data, or other relevant considerations, must be provided for applications proposing to study only one to nih guide notice on sex as a biological variable in nih-funded research for further consideration of nih expectations about sex as a biological your study(s) involves human subjects, the sections on inclusion of women and minorities and inclusion of children can be used to expand your discussion on inclusion and justify the proposed proportions of individuals (such as males and females) in the sample, but it must also be addressed here in the "approach" section of the "research strategy" out any procedures, situations, or materials that may be hazardous to personnel and the precautions to be exercised. A full discussion on the use of select agents should appear in the select agent research attachment research on human embryonic stem cells (hescs) is proposed but an approved cell line from the nih hesc registry cannot be chosen, provide a strong justification for why an appropriate cell line cannot be chosen from the registry at this onal instructions for sbir/sttr:Provide a tentative sequence or timetable for the you have multiple specific aims, you may address the significance, innovation, and approach either for each specific aim individually or for all of the specific aims applicable, also include the following information as part of the research strategy, keeping within the three sections (significance, innovation, and approach) listed inary studies for new applications:For new applications, include information on preliminary studies. Except for exploratory/developmental grants (r21/r33), small research grants (r03), and academic research enhancement award (area) grants (r15), preliminary data can be an essential part of a research grant application and can help to establish the likelihood of success of the proposed project. Early stage investigators should include preliminary onal instructions for sbir/sttr:Phase i applications: preliminary data are not required for phase i applications; however, such results may assist reviewers in assessing the likelihood of success of the proposed project and may be included in the research strategy ss report for renewal and revision applications:Note that the progress report falls within the research strategy and is therefore included in the page limits for the research renewal/revision applications, provide a progress report. For any studies meeting the nih definition for clinical research, particularly if relevant to studies proposed in the renewal or revision application. See nih's format attachments the titles and complete references to all appropriate publications, manuscripts accepted for publication, patents, and other printed materials that have resulted from the project since it was last reviewed m research products are considered allowable citations for applications submitted for due dates on or after may 25, 2017beginning with application due dates on or after may 25, 2017, you are allowed to cite interim research products.
See related frequently asked questions on citing interim research products and claiming them as products of your nih e the nih manuscript submission reference number (e. R&r other project information you answered "no" to the "are human subjects involved" question but your proposed research involves human specimens and/or data from subjects, you must provide a justification in this attachment for your claim that no human subjects are this information as a pdf file. See nih's format attachments not use the "protection of human subjects" attachment to circumvent the page limits of the research to supplemental instructions, part ii for instructions on this section. Additionally, be sure to follow any specific instructions in your more information:Refer to the nih's research involving human subjects onal instructions for multi-project:Overall component: the "protection of human subjects" attachment is optional unless specifically requested in the components: the "protection of human subjects" attachment is required if you answered "yes" to the question "are human subjects involved? Data safety monitoring must complete the "data safety monitoring plan" attachment:Include a "data safety monitoring plan" attachment if you answered "yes" to the question "clinical trial? 5: data and safety monitoring plan for instructions on this onal instructions for multi-project:Overall component: the "data safety monitoring plan" attachment is optional unless specifically requested in the components: the "data safety monitoring plan" is required if you answered "yes" to the question "clinical trial? R&r other project information form and the research does not fall under exemption this information as a pdf file. Nih policy on the inclusion of women and minorities in clinical research) for more information on submitting the phs inclusion enrollment report as part of your onal instructions for multi-project:Overall component: the "inclusion of women and minorities" attachment is optional unless specifically requested in the components: the "inclusion of women and minorities" is required if you answered "yes" to the question "are human subjects involved? R&r other project information form and the research does not fall under exemption 4. R&r other project information form and the research does not fall under exemption research plan section. See nih's format attachments not use this attachment to circumvent the page limits of the research vertebrate animals are involved in the project, address each of the following criteria:Description of procedures: provide a concise description of the proposed procedures to be used that involve vertebrate animals in the work outlined in the "research strategy" attachment. If dogs or cats are proposed, provide the source of the ications: provide justification that the species are appropriate for the proposed research. In addition to the 3 points above, you should also:Identify all project/performance or collaborating site(s) and describe activities of proposed research with vertebrate animals in those n when and how animals are expected to be used if plans for the use of animals have not been the following pages for more information:Nih's office of laboratory animal welfare 's vertebrate animals section mental instructions, part iii, section 2. Select agent must complete the "select agent research" attachment:Include a "select agent research" attachment if your proposed activities involve the use of select agents at any time during the proposed project period, either at the applicant organization or at any performance this information as a pdf file. Department of agriculture (usda) as having the potential to pose a severe threat to public health and safety, to animal and plant health, or to animal and plant products. Use this "select agent research" attachment to identify the strain(s) of the select agent that will be used and note that it has been excluded from this list. The cdc maintains a list of exclusions, which is available on the select agents and toxins exclusions ng for a select agent to be excluded: if the strain(s) is not currently excluded from the list of select agents and toxins but you have applied or intend to apply to hhs for an exclusion from the list, use this section to indicate the status of your request or your intent to apply for an exclusion and provide a brief justification for the applicants proposing to use select agents: address the following three points for each site at which select agent research will take place. Although no specific page limitation applies to this section, be fy the select agent(s) to be used in the proposed e the registration status of all entities* where select agent(s) will be the performance site(s) is a foreign institution, provide the name(s) of the country or countries where select agent research will be performed. Multiple pd/pi leadership must complete the "multiple pd/pi leadership plan" attachment:Any applicant who designates multiple pd/pis (on the g. R&r senior/key person profile (expanded) form) must include a multiple pd/pi leadership plan. R&r senior/key profile (expanded) form, even those at organizations other than the applicant not submit a multiple pd/pi leadership plan if you are not submitting a multiple pd/pi onal instructions for multi-project:Overall component: the "multiple pd/pi leadership plan" attachment is required if more than one pd/pi is specified on the overall component's g. The governance and organizational structure of the leadership team and the research project should be described, including communication plans, processes for making decisions on scientific direction, and procedures for resolving conflicts. The roles and administrative, technical, and scientific responsibilities for the project or program should be delineated for the pd/pis and other budget allocation is planned, the distribution of resources to specific components of the project or the individual pd/pis should be delineated in the multiple pd/pi leadership plan. Not include the same attachment in multiple onal instructions for sbir/sttr:Phase i applications: normally, a minimum of two-thirds or 67% of the research or analytical effort must be carried out by the small business concern (sbc).
Ii and phase iib applications: normally, a minimum of one-half or 50% of the research or analytical effort must be carried out by the sbc. I and phase ii applications: the basis for determining the percentage of work to be performed by each of the cooperative parties in phase i or phase ii will be the total requested costs (direct, f&a/indirect, and fee) attributable to each party, unless otherwise described and justified in this -track sbir applications: create two separate sections entitled "phase i consortium/contractual arrangements" and "phase ii consortium/contractual arrangements," and complete the sections following the instructions provided above for each -track sbir applications: create two separate sections entitled "phase i consortium/contractual arrangements" and "phase ii consortium/contractual arrangements," and complete the sections following the instructions provided above for each i, phase ii and phase iib sttr applications: at least 40% of the work must be performed by the sbc and at least 30% of the work must be performed by the single partnering research institution. The basis for determining the percentage of work to be performed by each of the cooperative parties will be the total of the requested costs (direct, f&a/indirect, and fee) attributable to each party, unless otherwise described and justified in this ication showing the cooperative r&d arrangement between the sbc and the research institution will be requested prior to an single partnering research institution must certify at the time of application that at least 30% of the work of the sttr project will be performed by the research institution. Requisite signature, printed name, title, and date of signature of the duly authorized representative of the research institution affirming certifications made by the research institution must be included in a letter stating:"the small business concern and the research institution certify jointly that: (1) the proposed sttr project will be conducted jointly by the small business concern and the research institution in which not less than 40 percent of the work will be performed by the small business concern and not less than 30 percent of the work will be performed by the research institution ("cooperative research and development"); (2) the proposed sttr project is a cooperative research or research and development effort to be conducted jointly by the small business concern and the research institution in which not less than 40 percent of the work will be performed by the small business concern and not less than 30 percent of the work will be performed by the research institution ("performance of research and analytical work"); and (3) regardless of the proportion of the proposed project to be performed by each party, the small business concern will be the primary party that will exercise management direction and control of the performance of the the research institution is a contractor-operated federally funded research and development center (ffrdc), the duly authorized representative of the contractor-operated federally funded research and development center certifies, additionally, that it: "(4) is free from organizational conflicts of interests relative to the sttr program; (5) did not use privileged information gained through work performed for an sttr agency or private access to sttr agency personnel in the development of this sttr grant application; and (6) used outside peer review, as appropriate, to evaluate the proposed project and its performance therein. Applicant sbc should convert the letter from the partnering research institution into a pdf attachment, and include it as part of this -track sttr applications: create two separate sections entitled "phase i consortium/contractual arrangements" and "phase ii consortium/contractual arrangements," and complete the sections following the instructions provided above for each phase. In addition, letters ensuring access to core facilities and resources should stipulate whether access will be provided as a s are not required for personnel (such as research assistants) not contributing in a substantive, measurable way to the scientific development or execution of the not include consultant biographical sketches in the "letters of support" attachment, as consultant biosketches should be in the "biographical sketch" section (see exception for sbir/sttr applications in the sbir/sttr-specific instructions). Instructions for sbir/sttr:Involvement of consultants and collaborators in the planning and research stages of the project is permitted. Also include biographical sketches for each s of interest from potential commercial partners or investors and letters of commitment of funds or other resources that will enhance the likelihood of commercialization should be placed following the letters of support for consultants and only: the single "partnering" research institution must provide a letter to the applicant small business concern certifying that at least 30% of the work of the sttr project will be performed by the research institution. See nih's format attachments sharing plan: investigators seeking $500,000 or more in direct costs (exclusive of consortium f&a) in any budget period are expected to include a brief 1-paragraph description of how final research data will be shared, or explain why data-sharing is not possible (for example human subject concerns, the small business innovation development act provisions, etc. Applicants are encouraged to read the foa carefully and discuss their data-sharing plan with their program contact at the time they negotiate an agreement with the institute/center (ic) staff to accept assignment of their application. For more information, see the nih data sharing policy or the nih guide notice on sharing research g model organisms: regardless of the amount requested, all applications where the development of model organisms is anticipated are expected to include a description of a specific plan for sharing and distributing unique model organisms or state why such sharing is restricted or not possible. 2: sharing model organism policy and the nih guide notice on sharing model organisms for biomedical c data sharing (gds): applicants seeking funding for research that generates large-scale human or non-human genomic data are expected to provide a plan for sharing of these data. Supplemental information to the nih gds provides examples of genomic research projects that are subject to the policy. The institutional certification, or in some cases, a provisional institutional certification, must be submitted and accepted before the award can be more information:Nih considers the sharing of unique research resources developed through nih-sponsored research an important means to enhance the value and further the advancement of the research. When resources have been developed with nih funds, and the associated research findings published or provided to nih, it is important that they be made readily available for research purposes to qualified individuals within the scientific community. A maximum of one page is more information:Key biological and/or chemical resources are characterized as biological and/or chemical resources may or may not be generated with nih funds and: 1) may differ from laboratory to laboratory or over time; 2) may have qualities and/or qualifications that could influence the research data; and 3) are integral to the proposed research. These include, but are not limited to, cell lines, specialty chemicals, antibodies, and other rd laboratory reagents that are not expected to vary do not need to be included in the plan. Applicants are encouraged to be as concise as possible and submit only information essential for the review of the not use the appendix to circumvent the page limits of the research strategy or any other section of the application for which a page limit applies. We provide information for new investigators and foreign applicants, as the advice provided is relevant for all research grants, it is general in nature and geared toward the nih research project (r01). Read them carefully for helpful hints on the information and content you should include in the application to garner a favorable ers will provide an overall impact score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria, and additional review criteria (as applicable for the project proposed). Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions? Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense? Have the investigators presented adequate plans to address relevant biological variables, such as sex, for studies in vertebrate animals or human subjects? If the project involves clinical research, are the plans for 1) protection of human subjects from research risks, and 2) inclusion of minorities and members of both sexes/genders, as well as the inclusion of children, justified in terms of the scientific goals and research strategy proposed?
For example, a project that by its nature is not innovative may be essential to advance a more about how applications are onal review applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit and in providing an overall impact score, but will not give separate scores for these tions for human ion of women, minorities, and sure to address any of these additional review criteria that apply to your application, as reviewers will consider them when assigning overall impact/priority : these are general review criteria for evaluating unsolicited research project grant applications. Applicants should look in the funding opportunity announcement to which they are applying and familiarize themselves with the review criteria by which their application will be onal review applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items and should not consider them in providing an overall impact ations from foreign ce sharing tication of key biological and/or chemical and period : certain funding opportunity announcements (foas) that are published in the nih guide for grants and contracts may list additional elements under each of the above criteria related to the specific requirement of the more about how applications are reviewed and scored on our peer review process ch resources, institutional support and available ient information must be included to demonstrate to reviewers and nih staff the high quality of the pd/pi, the co-investigators, available research resources, and the applicant institution and its support of the ants should clearly state that they have the appropriate resources to conduct the research, such as adequate equipment and laboratory space. When possible, include letters of commitment for these tand the level of resources needed to t an organizational ine what resources and support your organization has and what additional support you'll er whether the available equipment and facilities are adequate and whether the environment is conducive to the ndence and institutional support:This is important for all investigators, but particularly for new and early stage investigators or those who are early in their independent careers:Provide reviewers evidence that you have the appropriate experience and training to lead and manage the research s of reference and institutional commitment are n any start-up funds, support for a technician, etc. This is a positive indicator of institutional commitment to the peer orators and consultants:Determine the expertise needed for your research study team (individuals, collaborating organizations, resources, etc. Most scientific work requires collaboration among researchers, and nih is dedicated to fostering such e letters of commitment in your application that clearly spell out the roles of the collaborators. These letters are often the primary assurance the reviewers have that this work will in fact be consultants, letters should include rate/charge for consulting you are planning to apply with multiple-principal investigators, then take the following into consideration:The format, peer review and administration of applications submitted with multiple pis do have some significant differences from the traditional single-pi application. Therefore, it is essential to consider all aspects of the funding mechanism before applying, regardless of the type of research proposal to be applicants proposing team science efforts are strongly encouraged to contact their nih program officials at the earliest possible date to discuss the appropriateness submitting with multiple-pis for the support of their gh not a requirement for assignment purposes, you are allowed to request that the division of receipt and referral in the center for scientific review assign your application to a particular review group for initial peer review and to an nih institute or center for possible ers with expertise in your area will best recognize the potential for your research to advance science. It is important to match your area of research with the areas reviewed by the study you a new or early stage investigator? Reviewers instead place more emphasis on how the investigator has demonstrated that he or she is truly independent of any former mentors, whether he or she has some of his or her own resources and institutional support, and whether he or she is able to independently lead the n involvement: institution and/or n pd/pis and those from foreign institutions should ensure their eligibility by checking the eligibility guidelines provided in every n pd/pi's and those from foreign institutions are highly encouraged to contact a nih program officer as soon as possible in the planning and writing n applicants can learn more at our information for foreign applicants and grantees step will be one of your most time-consuming in the writing what type of budget will be required to submit with your application (found in your foa). The various components of the budget, working with your institution’s central grants office and department t nih program officials regarding allowability and other budgetary more information, see develop your research plan describes the proposed research, stating its significance and how it will be conducted. Any concerns the reviewers identify may negatively affect and postpone the granting of an graphy & references e a bibliography of any references cited in the research plan. Be especially careful to follow scholarly practices in providing citations for source materials relied upon when preparing any section of the and use of vertebrate animals in you are planning to use live vertebrate animals in the project, you must adhere to the requirements in the public health service (phs) policy on humane care and use of laboratory animals (policy): html version and pdf version. S tutorial: requirement for grantees using research tium/contractual n the programmatic, fiscal, and administrative arrangements to be made between the applicant organization and the consortium organization(s). Describe only those resources that are directly applicable to the proposed ion of women, minorities and children in reviewers will also assess the adequacy of plans to include subjects from both genders, all racial and ethnic groups (and subgroups), and children, as appropriate, for the scientific goals of the research will be assessed. Check out the nih inclusion of women and minorities policy website which has resources such as a decision tree to help you determine which of your studies are subject to nih’s inclusion applications designating multiple pds/pis, you must include a leadership tion of human subjects from research ants must assure nih that all human subjects are protected. Reviewers will assess the potential risk to human subjects in proposed research and evaluate what protections are in place to guard against any research-related risk. Awards cannot be made until assurances are on file with the office for human research protections (ohrp). Select agents are hazardous biological agents and toxins that hhs or usda have identified as having the potential to pose a severe threat to public health and safety, to animal and plant health, or to animal and plant products. This is because of the potential for providing a large amount of extra material from a web site beyond what would fit in the page limit, and thereby giving an unfair advantage to some applicants and a large additional burden for ant writing ’ve planned, you’ve researched, you understand the application…now it’s time to write. 1: make your project’s goals ’t propose more work than can be reasonably done during the proposed project you start writing the application, think about the budget and how it is related to your research plan. 4: sell your idea on e the reviewers’ attention by making the case for why nih should fund your research! A sloppy or disorganized application may lead the reviewers to conclude that your research may be conducted in the same er the details! Process does nih look of grant of your tand funding of your for text , track, and we check for d/corrected to apply video i: prepare to ii: write ation referraland -award and post-award -award and award award monitoring and ch about grants ication research intent & ce on research writing tip applications and summary statements (from niaid). Are herehome » about research planningthrough 27 institutes and centers, each with its own broadly defined mission, nih provides leadership and financial support to researchers in every state and throughout the year, federal funds are obligated by congress for the pursuit of research objectives.
Each institute determines how to allocate its own funds among many different activities of g research on-makers at nih seek advice from many sources when setting research priorities:The scientific community, including both individual researchers and professional societies;. Scientific management review board; nih builds its budget by evaluating current opportunities and public health needs while maintaining strong support for investigator-initiated research. The division of program coordination, planning, and strategic initiatives (dpcpsi) identifies important areas of emerging scientific opportunity or rising public health challenges to assist in the acceleration of research investments in these ific “peer” igator-initiated applications for nih funding are evaluated by peer review groups composed of scientists from outside the nih. These evaluations are used by the individual institutes to determine which projects to office of extramural research (oer) manages the development and implementation of policies and procedures that pertain to peer review conducted in all components of the -nih collaborations — involving multiple institutes and on of program coordination, planning, and strategic initiatives — provides direction and guidance for scientific programs funded by the nih common fund and develops new resources and tools to support the management and assessment of the nih scientific of science policy — advises the nih director on science policy issues affecting the medical research of legislative policy & analysis — provides legislative analysis, policy development, and liaison with the of extramural research — serves as the focal point for policies and guidelines for extramural research grants of intramural research — responsible for oversight and coordination of intramural research, training, and technology transfer conducted within of federal advisory committee policy — developing laws, regulations, and policies governing federal advisory ment performance and results act (gpra) — enhancing the effectiveness, efficiency, and accountability of government l reports archive — selected reports, budget requests, testimony, and research page last reviewed on april 4, happens to your nih grant application: an overview of peer reviewthis video shows how outside experts assess grant applications and how review meetings are conducted to ensure ch fundingsearch for research funding opportunities in the nih ed funding information on categories of nih for funded research projects through nih funding ch advancesread about key scientific discoveries supported by media & outreach.