Prostate cancer research paper
To clipboardadd to collectionsorder articlesadd to my bibliographygenerate a file for use with external citation management comment in pubmed commons belowexpert rev anticancer ther. Epub 2014 oct papers in prostate s1, shah tt, patel hr, arya information1division of surgery and interventional science, university college london, london, ctprostate cancer is the most common cancer and second leading cause of death in men. We aim to review and discuss past and contemporary papers on these topics to provoke debate and highlight key dilemmas faced by the urological community. We review key papers on prostate-specific antigen screening, radical prostatectomy versus surveillance strategies, targeted therapies, timing of radiotherapy and alternative anti-androgen therapeutics. Evidence is emerging that not all prostate cancers are alike and that low-grade disease can be safely managed by surveillance strategies and localized treatment to the prostate. Commentshow to join pubmed commonshow to cite this comment:Ncbi > literature > te cancer is cancer that starts in the prostate gland, which is a walnut sized gland at the base of the bladder in prostate msread about possible symptoms of prostate cancer and when to see your g diagnosedyour gp will ask you about your symptoms including what they are, when you get them and whether anything you do makes them better or and gradesfind out about number and tnm staging and the grades and types of prostate the stage of a cancer tells you how big it is and how far it’s spread. It helps your doctor decide which treatment you and causesprostate cancer is the most common cancer in men in the uk (not counting non melanoma skin cancer). Out about survival for prostate entyour treatment depends on where your cancer is, how big it is, whether it has spread anywhere else in your body and your general ch and clinical trialsfind out about the latest uk research, clinical trials and how you can take cal and emotional supportgetting practical and emotional support can help you cope with a diagnosis of cancer, life during treatment and life after ed canceradvanced prostate cancer means that a cancer that began in the prostate has spread to another part of the reviewed: 27 jun a clinical our clinical trials database for all cancer trials and studies recruiting in the to other people affected by helpline 0808 800 ons about cancer? Introduction prostate cancer (pca) is the most common cancer affecting men and the second leading cause of cancer death among american men (qaseem, denberg, owens, & shekelle, 2013). Medical professionals have been using prostate specific antigen (psa) screenings along with digital rectal exam (dre) for many years to screen for prostate cancer. We present a case of a patient with metastatic prostate cancer who developed severe hypocalcemia after the administration of the drug. The american cancer society states that cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. According to the centers for disease control and prevention, cancer is the second leading cause of death. Iology y prostate cancer was first described by a venetian anatomist niccolo massa in 1536 , it was not fully identified until 1853. Prostate cancer beleive it or not was actually first considered a rare disease,most likely because back then there was shorter life expectancy and poorer detection methods.. I reminisce with all members of my family the day we received the news from our doctor that my father had prostate cancer. We got that news like thunder in our ears, because just one year before we had lost our sister to breast cancer, and we still remember how much pain and suffering the cancer had caused. My father suffered prostate cancer for nearly two years, because the cancer had already spread to his bones.... Introduction studies have shown that that 25% of men that are diagnosed with cancer are usually diagnosed with prostate cancer. Chemotherapy is a treatment that using the bloodstream spreads all over the body to repair and kill cancer cells....
Prostate cancer and nutrition clinical radiation prostate cancer is the most common cancer of men and the third most common cause of death from cancer. Screening for this cancer is usually done by a digital rectum exam (dre) and/or prostate specific antigen test (psa). Rectum exam is the palpation of the prostate through the anus to check the size of the prostate. Prostate specific antigen test is a blood test to check if the prostate is releasing this specific antigen in the blood stream which can be a strong indication of prostate cancer.... Area of interest prostate cancer being a huge cause of mortality and medical expense in men age forty and above has only recently become a topic of general conversation to men in america (plowden, 2009). African-american men are affected by prostate cancer at a disproportional level than all other men. The african-american male is also less likely to take advantage of free prostate cancer screening (oliver, 2007).... Prostate cancer cancer of the prostate, a common form of cancer, is a disease in which cancer (malignant) cells are found in the prostate. The prostate is on the male sex glands, and is located just below the bladder and in front of the rectum. Prostate cancer imaging with 18f-fluorocholine a combination of prostate-specific antigen (psa) testing and transrectal ultrasound-guided biopsy is generally used for the detection of prostate cancer [17]. However, conventional prostate biopsy, even using 6–12 needle samples, is susceptible to sampling error with a false- negative rate as high as 30–40% [18, 19]. In addition, postradiotherapy prostate biopsies are prone to problems in interpretation (due to the presence of radiation effects and the lack of knowledge of the time required for residual tumour to become nonviable after radiation [20]) and transrectal ultrasound-guided sextant biopsy typically understages disease in patients with... Prostate cancer is the most commonly diagnosed cancer and the second most common cause of cancer death in men. Ernstoff,heaney,peschel,1998,pviii) like all cancers, prostate cancer is an uncontrolled cell production in a particular organ or area of the body. In the case of prostate cancer, these cells begin to split impulsively in the prostate and form tumors.... Thus, this consists of years of life lost (ylls) and years of healthy life lost (ylds) (aihw, cancer in australia an overview). Yld for cancers can include adverse effects of treatment including chemotherapy, and further psychosocial effects. Crc has both a high yll and high yld, with 2010 figures placing it second for ylls (55, 800 ylls), and third for ylds (12, 400 ylds) (aihw, cancer in australia an overview).... Between 4 to 10 ng/ml is 25% of developing cancer, and > 10 ng/ml is a > 50% risk of cancer. However, some men with normal psa levels still have prostate cancer, while other men with high psa levels do not.
Psa levels increase with age often due to a higher prevalence of benign prostate hypertrophy (bph). Therefore, no psa cutoff can accurately guarantee that a man does not have prostate cancer. Psa blood levels are used for several different purposes such as to diagnose prostate cancer, evaluate treatment of prostate cancer, and to evaluate the severity of benign prostatic hyperplasia (bph).... Lncap xenografts mimic many of the features of human prostate tumors making them a valuable model to study the mechanism of progression to crpca (12, 18). Prostate cancer is a leading cause of mortality and medical expense in men age forty and above. African-american men are affected by prostate cancer at a disproportionate level over all other men. So why is the african-american male less likely to take advantage of prostate cancer screenings even when it is free (oliver, 2007).... Cancer is a horrible disease that takes thousands of loved ones from their families every year, while millions of dollars are being pumped into cancer research, in hope to find a cure. An area of cancer research that does not get much publicity is epigenetics, which is the study of the heritable changes in dna that do not affect the dna sequence itself. Epigenetics plays a significant role in understanding the heritable functions of dna and how cancer is formed. Colorectal cancer: colorectal cancer, also known as bowel cancer, is found in the colon and the rectum and has become one of the most common forms of malignant cancer (cross & underwood, 2013). Approximately 50% of cancers have been located in the rectum, and 30% have been in the sigmoid colon (cross & underwood, 2013). Cancers found in the rectum are usually ulcer type tumours which are easily detected by rectal bleeding (cross & underwood, 2013). Colorectal cancer is the second most common cancer diagnosed in males and females (aihw, 2012a).... For years the go to cancer treatment has been very invasive and often created hardships for patients. Today we are on the fast track of a breakthrough that could redefine typical cancer treatments, one that could and will save thousands who are at risk. Million people worldwide died from cancer alone in 2013, with that number growing each year (cdc 2014). It would be unlikely that there will ever be a single cure for all cancers.... These cells include the lining or tissue of an organ or in the skin (australian institute of health welfare & australasian association of cancer, 2012). There are two types of carcinoma cells, basal cells and squamous cells (american cancer society, 2012).
Basal cell carcinomas are the cells that develop in the basal cell layer of the epidermis (american cancer society, 2012). Squamous cell carcinomas are cells that are more likely to develop in the fatty tissue beneath the skin (american cancer society, 2012).... Understanding the prostate the prostate is a gland part of the male reproductive system; it is located below the bladder and above the rectum surrounding all the way around the first portion of the urethra below the bladder. One of the most common prostate problem is benign prostate growth that, over time, can compress the urethra and cause difficulty to urinate. History of the prostate gland the prostate is a gland that is located just underneath the bladder. With an increase in the number of annual deaths caused by cancer in the us population, there have been many efforts by numerous private and public entities to create programs aimed at prevention of certain types of cancer. The purpose of this paper is to summarize the every woman matters program (ewm), its' ineffectiveness and the reasons as to why the program was unsuccessful. Being diagnosed with cancer has always been taken as a death sentence by a majority of the population. This can partly be contributed by the fact that most people do not understand clearly what cancer is. The way most reporters and some journalist have reviewed information relating to prostate cancer has been hazardous. Proper cancer treatment, especially prostate cancer in men is possible as reviewed in this article. The article is a citation from the referenced materials and sources in which it is possibly saying, cancer gets presented as any other form of illness hugely misinterpreted and one that can easily be cured.... In addition, the word cancer is a general name given to over 100 diseases, which begin with uncontrolled cellular growth. Mesothelioma is a cancer that is easily mistaken for lung cancer but is actually a cancer in the lining of organs within the body called the mesothelium; it can affect a person mostly in the chest cavity and in the abdominal. Smoking is not a prime cause of mesothelioma, but a combination of smoking and exposure to asbestos increases the risk of developing the cancer and sometimes it’s found to be genetic.... According to the american cancer association, there will be one and a half million new cancer diagnosis in the united states this year. Following heart disease, cancer is the second leading cause of death in the united states. The last two decades brought significant molecular biology and genetic knowledge into cancer and treatment options. Effective cancer screening methods are used to detect or identify the presence of a specific cancer before the individual displays any symptoms of cancer. Early detection of a cancer through screening can save the life of a person who may have died without screening detection.
Early detection of cancer can also provide a less costly and more effective treatment than if the cancer progresses requiring more advanced or drastic treatment. Screenings tests for the more common cancers such as breast, colon, prostate or cervical can be non-invasive or only slightly invasive.... Cancer is defined as a rapid, uncontrollable division of abnormal cells that can metastasize and spread to other areas of one’s body. This year alone, approximately “585,720 americans are expected to die of cancer, almost 1,600 people per day” ("cancer fact & figures 2014"). Therefore the purpose of this paper is to explain the five more common types of cancer americans are most frequently diagnosed with, as well as the symptoms associated with each type; factors that could potentially cause cancer and those who are more at risk or susceptible of developing any form of cancer; also ways to detect cancer, treat cancer and the s... Cancer is a health condition in which certain cells of the body multiply and mutate unexpectedly and uncontrollably, eventually leading to several health problems and complications. In some cases, cancer can be benign; in others, it can be malignant, and possibly life threatening. Also, cancer can affect any area of the body, including the breast, prostate, thyroid, brain, pancreas, lungs, and other parts of the body. Although cancer has existed for centuries and technology has evolved rapidly, this health condition, however, currently has no cure.... I will discuss how the cancer affects the normal operation of the esophagus, what causes esophageal cancer, how the cancer can be detected and how this cancer can be treated, i will conclude with a discussion of how common esophageal cancer is. Firstly, in hopes of understanding what esophageal cancer is, one must first understand what the esophagus is. Cancer is the 2nd and diabetes is the 7th leading cause of death in the u. Epidemiologic evidence suggests that people with type ii diabetes have an increased risk of liver, endometrium, pancreas, colorectum, bladder, breast and total cancer, but a decreased the risk of prostate cancer.... Cancer cells exhibit the distinctive metabolisms contrary to the normal cells, not only energy production depending on aerobic glycolysis but the dysregulatedcell signaling and mechanism,the increasing of fatty acid synthesis and glutaminolysisare obviously observed. 2013)simultaneously, intrinsic and extrinsic molecular mechanisms have been changed, in order to alter cellular metabolisms to meet the demand of nutrient in the rapid growth of cancer cells, commonly carbohydrate, protein, lipid and nucleic acid are the essential sources for which cancer cells need to support their growth and dividing.... Cancer is the second leading cause of death in america with the first being heart disease. Most people know someone who has cancer, who has died of cancer, or who survived cancer. Expanding your knowledge on lung cancer can save your life or the life of someone you may know. Learning about the demographics and statistics of lung cancer might make you realize that it is a serious issue that should be taken more into consideration. Here, you will get an understanding on how to prevent lung cancer from happening, and you will also learn how to treat lung cancer if diagnosed.
Lung cancer occurs when a person has abnormal cells that are uncontrollably growing in one or both lungs.... Hispanics, asian americans, and american indians has lower rates of bladder cancer increases with age. Studies suggest that chronic bladder inflammation, a parasitic infection called schistosomiasis, and some medications used to treat cancer are other environmental risk factors associated with bladder cancer.... Lung cancer is a life threatening disease, which is taking the lives of more and more people each day. There are two types of lung cancer, non-small cell lung cancer and small cell lung cancer. Lung cancer forms tumors in the lungs, which affects the quality of the lung and eventually the amount of gas exchange that can occur. Non- small cell lung cancer (nsclc) is the most prevalent type, accounting for more than 80 percent of cancer cases (walker. The mortality rate for lung cancer is shocking, in 2012 it is estimated that lung cancer will cause about 29 percent of all cancer deaths among men and 26 percent among women in the united states.... Cancer is a group of more than 100 different diseases which characterized by uncontrolled cellular growth, local tissue invasion and distant metastasis (chabner, 2006). The reputed british oncologist willis has defined cancer as "an abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of the normal tissues and persists in the same excessive manner after cessation of the stimuli which evoked the change" (cotran et al. Lung cancer: definition: according to the national cancer institute (2009), lung cancer refers to the uncontrolled and abnormal proliferation of lung tissue, usually in the cells lining air passages1. Classification: the international classification of disease, icd-10 classifies lung cancer under c34 as malignant neoplasm of the bronchus and lung2. Diet also lead people to cancer, consumption of red meat in big amount with specific amount of time could lead to intestine cancer. People who are obese have a higher risk of cancer than the normal people are. Treatment people with cancer must be treated with particular treatment as it’s a state where they could be really sensitive about themselves and about the disease, cancer not only makes people down physically but also attack people’s mentality.... Cancer cells often travel to other parts of the body where they can grow and form new tumors in a process called metastasis. For example, about half the people diagnosed with lung cancer live for at least 5 years after diagnosis, but if the lung cancer has metastasized to other areas of the body the survival rate for people is 4 percent, states the mayo clinic. This just shows how harder it is for doctors to treat patients with metastasized cancers.... I’m sure everyone has known someone who has had cancer before, or may have even experienced it themselves. This illness has taken many lives but there has been an abundance amount of people that have survived and currently living cancer free lives.
In the recently published report from the international agency for research on cancer (iarc), the specialized cancer agency for research on cancer of the world health organization (who), the global burden of cancer has been expected to almost double in the next decade. This trend is not only limited to the cancer incidence but is expected to be replicate in the cancer death or even more [1]. Bone cancer is a type of cancer in the bones where the cause is not yet known. Researchers are trying to find new and improved ways of treating this type of cancer. Some background information is stated so new research and new treatments could be understood better. Secondary bone cancer is diagnosed when the cancer starts elsewhere and spreads to the bone. For example, when someone has breast, prostate, or lung cancer and end up getting bone cancer because the cancer spreads to the bone is described as secondary bone cancer.... The disease of course is cancer, and it is a world wide battle to combat and find a cure for this awful and painful disease. The term “breast cancer” refers to a malignant tumor that has developed from cells in the breast” (breast cancer,n. If men can have abnormal cell growths in the breast, they are except-able to breast cancer as well. Men need to be aware of the prevention, diagnoses, and treatments for male breast cancer. When a person receives five or more sunburns, the chance of getting skin cancer more than doubles. If individuals in the united states continue to ignore the warnings and recommended precautions of sunscreen, the amount of those diagnosed with skin cancer will increase greatly within the next decade.... Stomach cancer," 2014) in addition to detection and treatment difficulties, finances can pose a major dilemma to the improvement of the sick patient as well. As alanna kennedy, a writer for the american association for cancer research, stated concerning the cost of cancer care, "a diagnosis of cancer is never easy, but it can be even more stressful when you’re struggling to pay for costly treatments and medications. Introduction breast cancer is one of the most common types of cancer in women and 70 percentage of breast cancer is caused by the over expression of estrogen receptor (er). It is targeted by pharmaceutical agents for hormone replacement in menopausal women and reproductive cancers such as prostate cancer, uterine cancer and breast cancer [1]. Oncogenes, also known as “cancer promoting genes”, are specific genes whose mutations can lead to the excessive proliferation of cells and lead to the development of cancer. They cause a “gain-of function mutation” which can lead a cell to a proliferative cancer form (alberts 2007). Whether or not someone answering their cell phone is increasing the likelihood of fatal brain cancer, is in question.
Apparently in recent years there has been much research completed looking for a solid answer to the question.... In 2008, there were an estimated 263,900 new cases and 128,000 deaths as a result of oral cavity cancer worldwide. Major risk factors for this specific type of cancer includes smoking, alcohol use, smokeless tobacco products, and hpv infections. Smoking is responsible for 42% of deaths from cancers of the oral cavity (including pharynx) and heavy alcohol consumption for 16% of the deaths worldwide; the corresponding percentages in countries with high income are approximately 70% and 30% respectively (ahmedin jemal, et a... The prostate is in the shape of a donut and about the size of a walnut. Normal functions of the prostate depend on the presence of the male hormone testosterone, which is produced by the testes.... A ping-pong disease that infects two to three million americans’ yearly worldwide and researchers have found that it can cause inflammation of the prostate in men but when women come in contact with trichomoniasis, their symptoms can consist of foul smells, heavily yellowish discharge that comes from the vagina area but then genitals in contact with the infection come across itching, and pain when urinating or having sexual intercourse.... The connection between diet and cancer cancer is a disease that can affect many different body parts. But no matter which body part is affected, cancer always involves cells that, due to various causes, go through genetic changes such that they start to proliferate wildly. In most forms of cancer the expanding masses of cells form tumors that eventually push against and invade neighboring tissue, disrupting body systems. At the top and bottom of the chromosomes are fragments of dna known as telomeres which defend our genes, give us the ability for our cells to divide, and hold secrets to how we age and how we get cancer. Such is the purpose of virotherapy – using viruses to selectively target and kill cancer cells, effectively stopping tumour growth in one fell swoop. In the war on cancer, the 200 types of cancer collectively claim almost half a million deaths yearly. Bone cancer is a very rare aggressive cancer that makes a considerable amount of pain in the bones of the patients. In most cases, bone cancer involves a tumor filled with abnormal cells that will usually appear on the exterior of the bone. Similar to other types of cancer, bone cancer causes much pain and can be life-threatening. My mother was diagnosed with primary bone cancer last year and it has been a very long, hard process for her and the whole family.... Cancer in united states cancer is one of the leading causes of death in the united states. Here are the most common cancer, breast cancer, colon cancer, head and neck cancer, leukemia, lung cancer, melanoma, non-hodgkins lymphoma, ovarian cancer, prostate cancer, and rectal cancer. Cancer is new growth of tissue resulting from rapid production of abnormal cells cancer is not a single disease but includes a number of diseases classified according to the tissue and type of cell in which new growth occurs, here are three major subtypes are sarcomas, carcinomas, leukemias and lymphomas.
Cancer is the second leading cause of death in the nation, and the leading cause of death from disease in children between the ages of 1 and 14.... Cancer today there are one in three people worldwide who are affected by cancer, and almost 60% of these people will almost certainly die. Cancer does not just affect certain groups of people, it can affect anybody and it is not just one disease, it refers to more than a hundred diseases. The mysterious face of cancer statement of purpose: what people need to understand though is yes cancer is life-altering chain of events but cancer is not the end of the world. If a patient does have cancer and it is detected in the early stages there is a greater chance of recovery. Cancer cancer is a group of diseases characterized by an uncontrolled growth of abnormal cells. Cancer cancer is a disease in which cells grow out of control and invade, erode, and destroy normal tissue. Cancer fewer than ten percent of most cancers are thought to be due to strong hereditary factors. One of those factors in prevention is the individual knowing their family history so that they can develop an awareness of their families' cancer lineage. Strong hereditary factors that increase cancer risk are more likely to be found in families that have: • individuals diagnosed with cancer at a younger than expected age (for example, breast cancer in the 40's or prostate cancer in the 50's) • three or... In the early 1990s almost 6 million new cancer cases developed and more than 4 million deaths from cancers occurred. Also more than one-fifth of all deaths were caused by cancer and it has been predicted, by the american cancer society, that about 33% of americans will eventually develop this disease. Cancer introduction in the american society, cancer is the disease most feared by the majority of people within the u. In the early 1990s nearly 6 million cancer cases and more than 4 million deaths have been reported worldwide, every year. The most fatal cancer in the world is lung cancer, which has grown drastically since the spread of cigarette smoking in growing countries. After months or years of fighting an uphill battle with cancer, there is finally a moment of peace when the word "remission" is spoken. Unfortunately, this word does not mean the cancer has been permanently cured, and some people never get to hear that word which is longed for from every cancer patient. In general, cancer is one of the leading causes of death in both children and adults. Unlike many other diseases, cancer is an extremely versatile illness; it can be found in many different forms with an uncountable number of causes.... Early detection of breast cancer has helped prevent many fatalities, but what if we had a vaccination for all types of cancer.
The pei (paul-ehrlich-institut,) which is the fda of germany, has found a way to get an accelerated approval to get a cancer vaccine called dcvax possibly approved by the usfda (united states food and drug administration). Over the past two and half years, a company by the name of northwest biotherapeutics has made major progress in finding a vaccination for all types of cancer through recent clinical trials.... Lung cancer lung cancer is not just one disease but rather a group of diseases. All forms of cancer cause cells in the body to change and grow out of control. When cancer spreads, it is still named after the part of the body where it started. For example, if breast cancer spreads to the lungs, it is still breast cancer, not lung cancer.... Lung cancer lung cancer is the number one killer of cancers of both men and women here in the united states. In 1999, it is estimated that 1,221,800 new cases of cancer are expected to occur and out of these 171,600 are to be cases of lung cancer. Meyer 1990) if lung cancer is the number one killer in the united states, one must wonder how it affects other countries around the world. One will find that the united states does not even have the worse statistics of death from lung cancer.... The link between heart disease and cancer recently, on a visit to my mothers' house, i pulled out my parents' wedding album. Colon cancer (identified as rectal cancer, colorectal cancer, bowel cancer) is well known as a malignancy that develops in the large intestine. Majority of colon cancers arise from outgrowths in the colon called polyps, which might or might not become malignant. In this case, however, variable metabolism results in variable levels of harmful dna adducts, and ultimately to cancer-causing mutations, rather than to adverse effects, as is case from chemotherapeutic treatments. It is now the most common male cancer, and the second or third most common cause of cancer-related death in men in the us and in europe [2,3]. Our new series, spotlight on prostate cancer, will address a broad range of research and clinical topics related to this common and important public health challenge. We welcome submissions of research articles covering prostate cancer epidemiology and prevention, screening and risk stratification, disease management and new therapies, biomarkers, molecular genomics, and translational the past three decades, we have witnessed tremendous shifts in the way that we approach prostate cancer. The introduction of prostate-specific antigen (psa) screening dramatically altered the presentation of the disease, but we are now moving away from a “one-size-fits-all” approach to new ways of individualizing screening. Better understanding of prostate cancer biology has led to the introduction of several new agents for advanced disease, transforming what had previously been a relatively barren field. Marker research has rapidly developed, with novel genomic markers now identifying the molecular drivers of aggressive disease.
Instead of administering hormonal treatment alone, we also attack the tumor-invaded organs with surgery or kill the cancer cells with we on the way to solving the quandary of prostate cancer, eloquently expressed by dr. This new series, spotlight on prostate cancer, will include commentaries as well as debate and opinion gh knowledge of the etiology of prostate cancer is still an area of investigation, evidence of nutritional and dietary targets for primary prevention is accumulating. In the review nutrition, dietary interventions and prostate cancer: the latest evidence, lin and colleagues provide an overview of recent literature on the possible influences of diet and nutrients on prostate cancer outcomes [4]. We have observed the rapid and dramatic increased incidence of the disease in the us, followed by a decrease in prostate cancer mortality [2], after the widespread implementation of psa testing, together with improvements in treatment [5]. We have followed the success of large-scale european screening trials that demonstrate a benefit of screening on prostate cancer mortality [6,7]. The commentary prostate-specific antigen based screening: controversy and guidelines, kim and andriole review the four largest randomized trials of screening and treatment and provide some reasons why these studies yielded apparently conflicting results [10]. Some could make the same claim about the trials of radical prostatectomy versus watchful waiting; the scandinavian spcg-4 trial [12] indicating “yes, radical prostatectomy works” and the us pivot trial [13] indicating “no, it does not”. While the american population was being heavily screened - essentially changing the question of the plco away from an evaluation of the effects of screening versus no screening - the european control population remained largely unscreened, and concomitantly, screening was shown to reduce prostate cancer mortality. Men in the scandinavian population in spcg-4 had clinically palpable, higher-risk disease, and surgery was abandoned for men with positive nodes; men in the american population in the pivot trial had mainly psa-detected, lower-risk disease, were older, and surgery was more to the heterogeneity of the disease, risk stratification has become an important aspect of screening, diagnosis, management, and treatment of prostate cancer. Modern management of prostate cancer now includes active surveillance, that is, monitoring the disease and delaying curative intervention until signs of disease progression. Our approach to high-risk disease is multidisciplinary, and we continue to make progress in the treatment of advanced prostate cancer with the advent of new drugs for castration-resistant disease, and finding the most effective sequence in which to administer them. Reports on prostate cancer management and treatment are encouraged and will be welcome in spotlight on prostate ing interestsav is named on a patent application for a statistical method to detect prostate cancer. Sc has no conflicts of interest to s’ contributionssc and av wrote the manuscript and approved the final manuscript submitted for s’ informationsc and av are the guest editors of our article collection spotlight on prostate cancer. Sc and av have more than 10 years of experience in the study of screening, early detection, and treatment of prostate cancer. Both are on staff at memorial sloan kettering cancer center, new york, ny, s’ affiliations(1)department of surgery (urology service), memorial sloan kettering cancer center(2)department of urology, institute of clinical sciences, sahlgrenska academy at university of göteborg(3)department of epidemiology & biostatistics, memorial sloan kettering cancer , zotero, reference manager, refworks (. On prostate – the prostate cancer research foundation, an randomized study of screening for prostate partnership with the european randomized study of screening for prostate ce for ’s prostate cancer risk calculator: from development to use in clinical in clinical : published findings relating to screening study (more ). Prostate-specific antigen(psa) isoform p2psa significantly improves the prediction of prostate cancer at initial extended prostate biopsies in patients with total psa between 2. A four-kallikrein panel predicts prostate cancer in men with recent screening: data from the european randomized study of screening for prostate cancer, rotterdam. Clin cancer res 2010;16(12): c h, van schaik rh, blijenberg b g, roobol m j, lilja h, stenman ulf-hakan. On the use of prostate-specific antigen for screening of prostate cancer in european randomised study for screening of prostate cancer.
Eur j cancer: 2010 (46) mj, steyerberg ew, kranse r, wolters t, van den bergh rc, bangma ch, et al. Prostate-specific antigen (psa) isoform p2psa in combination with total psa and free psa improves diagnostic accuracy in prostate cancer detection. Euro urol 2010; 57, 921 – here to go to theprostate cancer risk t information monique roobolrisk calculator feedback tell us what you think about the risk calculators and what your experience has would welcome your trisk surveillance and prias project.
