Research paper about dengue

There are no specific dengue therapeutics and prevention is currently limited to vector control measures. A dengue vaccine would therefore represent a major advance in the control of the of vaccine first dengue vaccine, dengvaxia (cyd-tdv) by sanofi pasteur, was first registered in mexico in december, 2015. Cyd-tdv is a live recombinant tetravalent dengue vaccine that has been evaluated as a 3-dose series on a 0/6/12 month schedule in phase iii clinical studies. It has been registered for use in individuals 9-45 years of age living in endemic ons and answers on cyd dengue recommends that countries should consider introduction of the dengue vaccine cyd-tdv only in geographic settings (national or subnational) where epidemiological data indicate a high burden of disease. Complete recommendations may be found in the who position paper on position paper on denguepdf, to support decision-making for the addition of the licensed dengue vaccine into a public immunization are approximately five additional vaccine candidates under evaluation in clinical trials, including other live-attenuated vaccines, as well as subunit, dna and purified inactivated vaccine candidates.

Dengue research papers

Additional technological approaches, such as virus-vectored and vlp-based vaccines, are under evaluation in preclinical growing global epidemic of dengue is of mounting concern, and a safe and effective vaccine is urgently needed. Who expects vaccines to be an integrated part of the global dengue prevention and control strategy (2012-2020). Report: global strategy for dengue prevention and control, 2012– working group on dengue vaccines and nges to vaccine ion by one of the four dengue virus serotypes has been shown to confer lasting protection against homotypic re-infection, but only transient protection against a secondary heterotypic infection. This and other observations suggest an immunopathological component in dengue pathogenesis, which is referred to as immune enhancement of disease. Due to these dengue-specific complexities, vaccine development focuses on the generation of a tetravalent vaccine aimed at providing long-term protection against all virus serotypes.

In spite of these challenges, vaccine development has made remarkable progress in recent years, and the current dengue vaccine pipeline is advanced, diverse and overall who initiative for vaccine research (ivr), in collaboration with a wide range of partners, aims to facilitate the development and future introduction of safe, effective and affordable dengue vaccines. Activities focus on the following main objectives:Identify knowledge gaps and research needs related to the development, evaluation and implementation of dengue scientific consensus and develop guidance on the evaluation of dengue and evaluate the evidence base for policy recommendations related to the introduction and use of dengue p guidance on vaccine implementation, including introduction t national regulatory authorities in their review of dengue vaccine registration d who ines for the clinical evaluation of dengue vaccines in endemic areas (2008). A: phase iib study of cyd-tdv (september 2012)pdf, l issue: the development of dengue vaccines (vaccine, volume 29, issue 42, pages 7219-7284, 23 september 2011). Technical advisory group on dengue vaccines in late stage fact sheet: dengue and severe global strategy for dengue prevention and control, who activities on vaccine initiative (dvi). June 2017 11:23 zation, vaccines and ch and e-specific areas of mmes and region of the south-east asia eastern mediterranean western pacific up for who ational scholarly research l menu about this journal ·.

Totable of contents of contents receive news and publication updates for international scholarly research notices, enter your email address in the box mation email ons to this to cite this t us | terms of service | privacy ncbi web site requires javascript to tionresourcesall resourceschemicals & bioassaysbiosystemspubchem bioassaypubchem compoundpubchem structure searchpubchem substanceall chemicals & bioassays resources... Review of dengue research in wk1, ng ks2, marzilawati ar2, lum information1hospital taiping, department of medicine, 34000 perak, malaysia. Malaya, faculty of medicine, department of paediatrics, 50603 kuala lumpur, ctdengue infection is a major cause of morbidity and mortality in malaysia. One hundred and sixty six articles related to dengue in malaysia were found from a search through a database dedicated to indexing all original data relevant to medicine published between the years 2000-2013. These papers showed evidence of an exponential increase in the disease epidemic and a varying pattern of prevalent dengue serotypes at different times.

Clinical suspicion and ability to identify patients at risk of severe dengue infection is important. Potential future research areas are discussed to narrow our current knowledge gaps on dengue infection. Commentshow to join pubmed commonshow to cite this comment:Ncbi > literature > sity news health & ch points to possible new route to fight dengue graphic depicts structures in the dengue virus that are critical for the infection process. Researchers have learned details about how the virus alters lipids in membranes surrounding structures called organelles, suggesting a potential new approach to control the aggressive mosquito-borne pathogen. Researchers have identified enzymes and biochemical compounds called lipids that are targeted and modified by the dengue virus during infection, suggesting a potential new approach to control the aggressive mosquito-borne gs also suggest that medications used to treat high cholesterol and other lipid-related conditions might also inhibit dengue's replication and could represent a potential new therapy.

The researchers have identified how infected mosquito cells undergo changes to certain lipids in membranes and in biochemical sensors that alert cells of invading viruses. The virus reorganizes the internal architecture of the cell to support its own needs," said purdue university research scientist rushika perera. The researchers uncovered new details of how the virus alters lipids in membranes surrounding structures inside cells called organelles, including the mitochondria, which provide energy critical for a cell to function, and the endoplasmic reticulum, where proteins and lipids are synthesized. It turns out, the pills you take to control your cholesterol might have some capability to control dengue. The work was led by perera in collaboration with researchers at purdue's bindley bioscience center and the pacific northwest national laboratory.

Findings are detailed in a research paper to appear thursday (march 22) in the journal plos findings could apply to viruses similar to dengue, including the west nile virus, yellow fever and hepatitis causes 50 million to 100 million infections per year and is considered one of the most aggressive mosquito-borne human pathogens worldwide. Many viruses, including dengue, dramatically alter a host cell upon infection, and in this paper we begin to dissect the precise changes that occur. Researchers showed that compounds inhibiting production of the enzyme also inhibit virus replication, suggesting drugs already on the market to treat diseases related to lipid synthesis and storage, including diabetes and cancer, also might be used to treat dengue, kuhn research paper was written by perera; kuhn; bindley researchers catherine riley, amber s. Researchers had previously studied a compound that inhibits the production of fatty acid synthase in human cells. In the new findings, the researchers showed that the virus commandeers some of the same enzymes in both mosquito and human cells, meaning the same compound could work to attack the virus in mosquito cells.

Globally, dengue has grown dramatically in recent decades, placing about half the world's population at risk of infection. The infection causes flulike illness and occasionally develops into a potentially lethal complication called dengue hemorrhagic fever. Prompt medical care for this severe form of dengue virus infection has been shown to decrease mortality rates from more than 20 percent to less than 1 percent, according to the world health research hinges on recent advances in two areas: high-resolution mass spectrometry and "informatics," or using computers to process volumes of information. The researchers also detail changes in the curvature of membranes, using another technique called cryoelectron microscopy, and pinpointed an isolated part of the cell where most of the virus replication takes place, a complex of membranes modified by the infection. The virus is thought to commandeer enzymes, relocating them to this region where virus replication factories are e the research tools enable scientists to see how changes in membranes and signaling lipids alter how a cell functions, a long-term benefit of the research is learning how to use a virus as a tool to better understand cellular processes, perera work is funded by the national institutes of health, and the team recently received a new nih grant to conduct research aimed at finding commonalities in how dengue infects humans and mosquitoes.

During its replication, dengue virus induces dramatic alterations in the intracellular membranes of infected cells. Using high-resolution mass spectrometry of mosquito cells, we show that this membrane remodeling is directly linked to a unique lipid repertoire induced by dengue virus infection. Furthermore, we demonstrate that intracellular lipid redistribution induced by the inhibition of fatty acid synthase, the rate-limiting enzyme in lipid biosynthesis, is sufficient for cell survival but is inhibitory to dengue virus replication. Lipids that have the capacity to destabilize and change the curvature of membranes as well as lipids that change the permeability of membranes are enriched in dengue virus infected cells. Several sphingolipids and other bioactive signaling molecules that are involved in controlling membrane fusion, fission, and trafficking as well as molecules that influence cytoskeletal reorganization are also up regulated during dengue infection.

These observations shed light on the emerging role of lipids in shaping the membrane and protein environments during viral infections and suggest membrane-organizing principles that may influence virus-induced intracellular membrane ght © 2009-12 purdue ght infringement university is an equal access/equal opportunity you have trouble accessing this page because of a disability, please contact purdue news service at purduenews@ research could provide hope for prevention and treatment of dengue your login details below. Impact factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. Sjr uses a similar algorithm as the google page rank; it provides a quantitative and a qualitative measure of the journal’s more on journal example article on lides are short, 5-minute presentations in which the author explains their paper in their own application allows readers to explore ncbi data on author-tagged genes through an interactive genetic sequence viewer that supports flipping strands, zooming to a sequence, selecting a specific position, and ctive plot application lets readers explore data and other quantitative results submitted with the article, providing insights into and access to data that is otherwise buried in hing your article with us has many benefits, such as having access to a personal dashboard: citation and usage data on your publications in one place. This free service is available to anyone who has published and whose publication is in research could provide hope for prevention and treatment of dengue virus. Study published in virology reveals ‘break and enter’ method in which the virus enters dengue virus is a mosquito-borne virus that has become a significant public health threat in recent years.

Originally confined to southeast asia, the dengue virus has now spread to southern china, africa, indonesia, australasia, latin america and the united year around 50 million people contract the virus, which causes fever, headache, muscle and joint pains, and a characteristic skin rash. What’s more, the main reasons for the spread of the virus include: urbanisation, global warming and a lack of mosquito control; all of which are still current issues and will continue to contribute to the geographical spread of the prominent theory has been that flaviviruses (the group in which dengue belongs) enter human cells by endocytosis or by fusing with the cell this study, researchers used electron microscopes to watch the early stages of the infection process, labelling the viruses while they entered cells. The results, published in virology, showed that rather than using a molecular ‘key’ to enter the cell, these viruses may infect cells by directly penetrating its tanding this process could provide researchers with an opportunity to develop treatments and vaccines, helping to protect the 2.